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    Gilead Sciences cal-120
    Cal 120, supplied by Gilead Sciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cal-120/cal+130/us12215156-1178-43-44
    Average 90 stars, based on 1 article reviews
    cal-120 - by Bioz Stars, 2026-10
    90/100 stars

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    other:

    Article Title: Methods and compositions for treating non-ERK MAPK pathway inhibitor-resistant cancers
    Article Snippet: Non-limiting examples of an inhibitor of the PI3K/Akt pathway include A-674563 (CAS #552325-73-2), AGL 2263, AMG-319 (Amgen, Thousand Oaks, Calif.), AS-041164 (5-benzo[1,3]dioxol-5-ylmethylene-thiazolidine-2,4-dione), AS-604850 (5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione), AS-605240 (5-quinoxilin-6-methylene-1,3-thiazolidine-2,4-dione), AT7867 (CAS #857531-00-1), benzimidazole series, Genentech (Roche Holdings Inc., South San Francisco, Calif.), BML-257 (CAS #32387-96-5), CAL-120 (Gilead Sciences, Foster City, Calif.), CAL-129 (Gilead Sciences), CAL-130 (Gilead Sciences), CAL-253 (Gilead Sciences), CAL-263 (Gilead Sciences), CAS #612847-09-3, CAS #681281-88-9, CAS #75747-14-7, CAS #925681-41-0, CAS #98510-80-6, CCT128930 (CAS #885499-61-6), CH5132799 (CAS #1007207-67-1), CHR-4432 (Chroma Therapeutics, Ltd., Abingdon, UK), FPA 124 (CAS #902779-59-3), GS-1101 (CAL-101) (Gilead Sciences), GSK 690693 (CAS #937174-76-0), H-89 (CAS #127243-85-0), Honokiol, IC87114 (Gilead Science), IPI-145 (Intellikine Inc.), KAR-4139 (Karus Therapeutics, Chilworth, UK), KAR-4141 (Karus Therapeutics), KIN-1 (Karus Therapeutics), KT 5720 (CAS #108068-98-0), Miltefosine, MK-2206 dihydrochloride (CAS #1032350-13-2), ML-9 (CAS #105637-50-1), Naltrindole Hydrochloride, OXY-111A (NormOxys Inc., Brighton, Mass.), perifosine, PHT-427 (CAS #1191951-57-1), PI3 kinase delta inhibitor, Merck KGaA (Merck & Co., Whitehouse Station, N.J.), PI3 kinase delta inhibitors, Genentech (Roche Holdings Inc.), PI3 kinase delta inhibitors, Incozen (Incozen Therapeutics, Pvt.

    Article Title: HER-2 targeted bispecific compositions and methods for making and using the same
    Article Snippet: Non-limiting examples of an inhibitor of the PI3K/Akt pathway include A-674563 (CAS #552325-73-2), AGL 2263, AMG-319 (Amgen, Thousand Oaks, Calif), AS-041164 (5-benzo[1,3]dioxol-5-ylmethylene-thiazolidine-2,4-dione), AS-604850 (5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione), AS-605240 (5-quinoxilin-6-methylene-1,3-thiazolidine-2,4-dione), AT7867 (CAS #857531-00-1), benzimidazole series, Genentech (Roche Holdings Inc., South San Francisco, Calif.), BML-257 (CAS #32387-96-5), BVD-723, CAL-120 (Gilead Sciences, Foster City, Calif), CAL-129 (Gilead Sciences), CAL-130 (Gilead Sciences), CAL-253 (Gilead Sciences), CAL-263 (Gilead Sciences), CAS #612847-09-3, CAS #681281-88-9, CAS #75747-14-7, CAS #925681-41-0, CAS #98510-80-6, CCT128930 (CAS #885499-61-6), CH5132799 (CAS #1007207-67-1), CHR-4432 (Chroma Therapeutics, Ltd., Abingdon, UK), FPA 124 (CAS #902779-59-3), GS-1101 (CAL-101) (Gilead Sciences), GSK 690693 (CAS #937174-76-0), H-89 (CAS #127243-85-0), Honokiol, IC87114 (Gilead Science), IPI-145 (Intellikine Inc.), KAR-4139 (Karus Therapeutics, Chilworth, UK), KAR-4141 (Karus Therapeutics), KIN-1 (Karus Therapeutics), KT 5720 (CAS #108068-98-0), Miltefosine, MK-2206 dihydrochloride (CAS #1032350-13-2), ML-9 (CAS #105637-50-1), Naltrindole Hydrochloride, OXY-111A (NormOxys Inc., Brighton, Mass.), perifosine, PHT-427 (CAS #1191951-57-1), PI3 kinase delta inhibitor, Merck KGaA (Merck & Co., Whitehouse Station, N.J.), PI3 kinase delta inhibitors, Genentech (Roche Holdings Inc.), PI3 kinase delta inhibitors, Incozen (Incozen Therapeutics, Pvt.



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    Image Search Results


    Overexpression of TBC1D22B, but not of TBC1D22A, induces tumor spheroids overgrowth, in a GAP‐dependent manner. BT549 cells stably expressing the empty vector (EV), HA‐tagged TBC1D22B, RQ or TBC1D22A were grown in matrigel for 7 days to form tumor cell spheroids. Spheroids were stained with Phalloidin and DAPI shown respectively in magenta and grey in the merged representative images (left). Images are confocal Z‐stack projections (8 optical sections/image) of spheroids acquired with a 40x objective, zoom 1.5x. Bar, 50 µm. Quantification of the spheroids area, shown in the middle panel, is from 3 independent experiments in which 45–71 spheroids/condition were measured. Mean ± SD are also shown in the plots. Statistical analysis was performed with the t‐test, **** p < 0.0001. The Western blots on the right were IB with the indicated antibodies (vinculin, loading control) and show the expression levels of TBC1D22B, RQ and TBC1D22A. B) CAL120 cells stably expressing the empty vector (EV), the HA‐tagged TBC1D22B, or RQ were grown and stained as in A. Images are confocal Z‐stack projections (8 optical sections/image) of representative spheroids acquired with a 20x objective, zoom 2. Bar, 50 µm. In the middle panel the area of 45 spheroids/condition from 3 independent experiments is shown. Mean ± SD are also shown in the plots. Statistical analysis was performed with the t‐test, p values: ***, p < 0.001, **** p < 0.0001. The Western blot on the right shows the expression levels of TBC1D22B and RQ.

    Journal: Advanced Science

    Article Title: TBC1D22B Regulates ER‐to‐Golgi Trafficking via RAB1B Inactivation and Promotes Oncogenic Programs in Breast Cancer

    doi: 10.1002/advs.202502269

    Figure Lengend Snippet: Overexpression of TBC1D22B, but not of TBC1D22A, induces tumor spheroids overgrowth, in a GAP‐dependent manner. BT549 cells stably expressing the empty vector (EV), HA‐tagged TBC1D22B, RQ or TBC1D22A were grown in matrigel for 7 days to form tumor cell spheroids. Spheroids were stained with Phalloidin and DAPI shown respectively in magenta and grey in the merged representative images (left). Images are confocal Z‐stack projections (8 optical sections/image) of spheroids acquired with a 40x objective, zoom 1.5x. Bar, 50 µm. Quantification of the spheroids area, shown in the middle panel, is from 3 independent experiments in which 45–71 spheroids/condition were measured. Mean ± SD are also shown in the plots. Statistical analysis was performed with the t‐test, **** p < 0.0001. The Western blots on the right were IB with the indicated antibodies (vinculin, loading control) and show the expression levels of TBC1D22B, RQ and TBC1D22A. B) CAL120 cells stably expressing the empty vector (EV), the HA‐tagged TBC1D22B, or RQ were grown and stained as in A. Images are confocal Z‐stack projections (8 optical sections/image) of representative spheroids acquired with a 20x objective, zoom 2. Bar, 50 µm. In the middle panel the area of 45 spheroids/condition from 3 independent experiments is shown. Mean ± SD are also shown in the plots. Statistical analysis was performed with the t‐test, p values: ***, p < 0.001, **** p < 0.0001. The Western blot on the right shows the expression levels of TBC1D22B and RQ.

    Article Snippet: CAL120 cells, from DSMZ, were grown in DMEM (ECM0749L, Euroclone) supplemented with 10% fetal bovine serum (ECS1800D, Euroclone), 1% L‐glutamine (ECB3000D, Euroclone) and 1% penicillin‐streptomycin (ECB3001D, Euroclone).

    Techniques: Over Expression, Stable Transfection, Expressing, Plasmid Preparation, Staining, Western Blot, Control